The purpose of this study is to determine if an eye tracking impairment sensor can detect cannabis-induced impairment after using cannabis.The overall objective is to correlate measures collected from the eye tracking sensor with measures related to cannabis impairment (e.g., plasma THC levels, self-reported cannabis subjective effects, cognitive effects).
The proposed project is a single-visit clinical laboratory study to evaluate the initial efficacy of an eye tracking sensor to detect cannabis-related impairment. Participants will be experienced but not frequent cannabis users without evidence of heavy alcohol or illicit drug use or other physical or mental health illness. Participants will come in for one screening visit, and those who consent, are eligible, and enroll will complete one experimental laboratory session involving smoking of 50% of 1 active (approximately 4.0% THC) cannabis cigarette. Assessments will be collected after-cannabis smoking up to 4 hours. Participants will be sent home from the laboratory via taxi.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DEVICE_FEASIBILITY
Masking
NONE
Enrollment
3
Device measures smooth eye pursuit and response to light flash after pt smokes cannabis
smoked cannabis 4.0% THC
Battelle Memorial Institute
Baltimore, Maryland, United States
Change from baseline in Pupil Dilation
Change in pupil dilation in different lights will be measured by the eye tracking sensor
Time frame: Before and after smoking (up to 240 minutes)
Change from baseline in Gaze Nystagmus
Change in Gaze Nystagmus will be measured by the eye tracking sensor
Time frame: Before and after smoking (up to 240 minutes)
Change from baseline in Lack of Convergence
Change in Lack of Convergence will be measured by the eye tracking sensor
Time frame: Before and after smoking (up to 240 minutes)
Plasma THC
Plasma concentration before and after smoking
Time frame: Before and after smoking (9 timepoints up to 240 minutes post smoking)
Change from baseline in Cannabis Subjective Effects
Scores for the question "do you feel a drug effect" are measured on a 0-100 point visual analogue scale to measure change in marijuana intoxication across timepoints.
Time frame: Before and after smoking (up to 240 minutes post smoking)
Change from baseline in Four Choice Reaction Time Task
Will assess changes in psychomotor/cognitive performance known to be sensitive to the acute effects of smoked cannabis.
Time frame: Before and after smoking (up to 240 minutes post smoking)
Change from baseline in Digit Symbol Substitution Task
Will assess changes in psychomotor/cognitive performance known to be sensitive to the acute effects of smoked cannabis.
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Time frame: Before and after smoking (up to 240 minutes post smoking)