Prevalence of Wild Type Transthyretin Cardiac Amyloidosis in Patients Operated for Idiopathic Carpal Tunnel Syndrome

Aarhus University Hospital Skejby120 enrolled

Overview

Wild-type transthyretin cardiac amyloidosis is an underdiagnosed depository disease in which fibril monomers of misfolded amyloid protein accumulates in various tissues, including the heart, and cause tissue dysfunction. Before onset of cardiac symptoms, many patients will have undergone surgery for idiopathic carpal tunnel syndrome since the protein also deposits in the transversal carpal ligament of the hand. This study investigates patients previously operated for idiopathic carpal tunnel syndrome to determine if they display signs and symptoms of cardiac amyloidosis.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

120

Conditions

Amyloidosis Cardiac Carpal Tunnel Syndrome

Interventions

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients above sixty years of age previously operated for idiopathic carpal tunnel syndrome within the Region of Central Denmark (Region Midtjylland) the last five years. * Informed written and verbal consent Exclusion Criteria: * Operation by different indication such as * Fracture * Ganglion * Tumors * Osteophytes * Rheumatoid Arthritis * Persistent medial artery * Metabolic causes * Alcoholism * Hyperthyroidism * Myxedema * Hereditary Cardiac Amyloidosis * Known WT ATTR * AL Amyloidosis * Myelomatosis * MGUS and Morbus Waldenström

Outcomes

Primary Outcomes

Prevalence of cardiac amyloidosis.

The prevalence of cardiac amyloidosis among patients previously operated for ipiopathic carpal tunnel syndrome.

Time frame: Through study completion, an average of 2 years.