Gene therapy is a promising strategy to treat hearing loss and vestibular disorders, and Associated adenovirus (AAV) is shown as a good viral vector for inner ear therapy in animal models. This study aims to study in vitro viral transduction of AAV in human inner ear cells, collected during non-conservative surgeries for vestibular schwannoma.
Study Type
OBSERVATIONAL
Enrollment
100
After obtaining an informed consent during the preoperative medical visit, and if a non-conservative approach (translabyrinthine or transotic) is decided, the collect of inner ear cells will be performed during surgical approach. The sample will be collect in a sterile tube, and carried to the laboratory were it will be placed bon cell culture.
Hôpital de Bicêtre
Le Kremlin-Bicêtre, Île-de-France Region, France
RECRUITINGHôpital Pitié-Salpétrière
Paris, Île-de-France Region, France
RECRUITINGAAV transduction in inner ear cells
The transduction will be measured with immunostaining techniques
Time frame: 10 days
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