Objectives: To compare the safety and efficacy of IV aminophylline versus IV neostigmine/atropine mixture in the treatment of post-dural puncture headache (PDPH). Background: PDPH is the most frequent complication of procedures associated with dural puncture for spinal anesthesia or following accidental dural puncture during epidural anesthesia. Since invasive treatments have known complications, pharmacologic management may be preferable. Patients and Methods: This was a prospective, randomized, double-blind, phase four clinical trial; carried out on 60 patients presented with PDPH at our hospital. Patients were randomly allocated into two equal groups (30 patients each); group A, received IV aminophylline, and group NA, received IV neostigmine/atropine mixture.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
60
IV Aminophylline (100 mg/8h)
IV Neostigmine/Atropine mixture (20 μg/kg Neostigmine + 10 μg/kg Atropine)/8h
Damanhour Teaching Hospital
Damanhūr, El-Beheira, Egypt
Median and Range of Numeric Pain Rating Scale (NPRS) score
NPRS measures the severity of PDPH, it is a 11 point scale from 0-10; where 0=No pain and 10=Worst possible pain (before, 2h, 6h, 12h, then every 12h till 48h)
Time frame: 48 hours after initiation of treatment
Mean and Standard deviation of PDPH duration (hours) (mean±SD)
Time from PDPH onset till NPRS score ≤ 3
Time frame: 48 hours after initiation of treatment
Number of participants and Rate of Treatment-related complications
Number of participants and Rate of: Diarrhea, Palpitation, Abdominal cramps, Muscle twitches, Bronchospasm, Urinary bladder hyperactivity
Time frame: 48 hours after initiation of treatment
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.