Children were exposed to biodiverse material or non-diverse material in sand pits. The two arms were compared. Immune response and bacterial markers were followed.
Children of age 3-5 were randomly divided into two groups (arms). One received guidance and biodiverse material for 20 minutes each day for two weeks. The other received the a similar material and guidance but the microbial community in the material was poor in diversity. Bacterial community changes and immune system markers were analyzed and compared between the two arms. Potential changes in Interleukin 10 was the primary outcome.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
25
Biodiversity sand contained biodiversity powder that contains a highly diverse and rich microbial community but no known pathogens.
Sand that looks like intervention sand but does not have high biodiversity
Helsinki University
Lahti, Kanta-Häme, Finland
Change in Interleukin 10 level in blood
The difference between day 0 and a follow up day in intervention
Time frame: two weeks
changes in microbiota
all potential changes in bacterial profile are measured on skin and stool samples
Time frame: two weeks
changes in interleukin 17 levels
all measured changes in interleukin 17 levels
Time frame: two weeks
changes in tgf-beta levels
change in tgf-beta levels
Time frame: two weeks
ratio il-10 / il-17
potential changes in the ratio of these two citokines
Time frame: two weeks
long-term changes in microbiota
potential changes that last for four weeks
Time frame: four weeks
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