Intravenous Thrombolysis Registry for Acute Ischemic Stroke in China

Inclusion Criteria: * 1\) age\> 18 years old; * 2\) meet the diagnostic criteria of China 2014 guidelines for the diagnosis and treatment of acute ischemic stroke; * 3\) no history of first sepsis or previous cerebral infarction sequelae (mRS ≤ 1); * 4\) within 3 hours of onset; * 5\) Have measurable neurological deficits; * 6\) Patients or legal guardians can understand and sign informed consent. Exclusion Criteria: * Absolute exclusion criteria: * 1\) history of head trauma or stroke within the last 3 months; * 2\) suspected subarachnoid hemorrhage; * 3\) history of previous intracranial hemorrhage; * 4\) intracranial tumor, arteriovenous malformation or aneurysm ; * 5\) recent intracranial or intraspinal surgery; * 6\) arterial puncture at an incurable site within the last 7 days; * 7\) elevated blood pressure: systolic blood pressure ≥180 mm Hg, or diastolic blood pressure ≥100 mm Hg; * 8\) Internal bleeding; * 9\) acute bleeding tendency, including platelet count less than 100 × 109 / L or other conditions; * 10\) heparin treatment within 48 h (APTT is outside the upper limit of normal range); * 11\) oral anticoagulant, INR\> 1.7 Or PT\> 15S; * 12\) are currently using thrombin inhibitors or factor Xa inhibitors, various sensitive laboratory abnormalities (such as APTT, INR, platelet count, ECT; TT or appropriate factor Xa activity assays) ; * 13\) Blood glucose \<50 mg / dl (2.7 mmol / L); * 14\) CT suggestive of multiple cerebral infarction (low density range\> 1/3 of the cerebral hemispheres) ; * 15\) Other conditions considered unsuitable for inclusion in this clinical study; * 16\) 3 months or are participating in other clinical trials; * 17\) combined with severe systemic disease is expected to survive less than three months. * Relative exclusion criteria: * 1\) severe stroke (NIHSS\> 25 points); * 2\) pregnancy; * 3\) neurological deficits after epileptic seizures; * 4\) major surgery or severe trauma within the last 14 days; * 5\) Urethral hemorrhage; * 6\) Myocardial infarction within the last 3 months;