This study is designed to assess and to evaluate the therapeutic effect of retrobulbar injection of autoserum in the treatment of retinitis pigmentosa.
The retinitis pigmentosa(RP) is an hereditary disease which causes visual deficiency leading to blindness. The methods of treatment include gene therapy, stem cell therapy and visual prothesis, etc. But all these methods own limitations can not be conquered in a short period. It was proved that vascular endothelial growth factor (VEGF) and pigment epithelium derived factor (PEDF) decreased in the aqueous humor of patients of RP. But the traditional exogenous nerve growth factors (NGFs) were immunogenic proteins and may cause inflammation. Autoserum contain a large amount of active factors and will not cause exclusive reaction. In this study we aim to assess and to evaluate the therapeutic effect and the safety of retrobulbar injection of autoserum in the treatment of retinitis pigmentosa.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
30
Retrobulbar block is usually a type of regional anesthetic nerve block used in intraocular surgery. In this technique, local autoserum is injected into the retrobulbar space for the neurotrophic purpose.
Retrobulbar block is usually a type of regional anesthetic nerve block used in intraocular surgery. In this technique, normal saline (NS) is injected into the retrobulbar space as a comparison
Change of the visual acuity
To measure the visual acuity with logarithmic visual chart.
Time frame: one day before injection, one day, one month, three months and six months after surgery
Change of the contrast sensitivity
To access the change of contrast sensitivity in different special frequency.
Time frame: one day before injection, one month, three months and six months after surgery
Change of the electrophysiological detection (flash electroretinogram)
To evaluate the retinal function with the use of flash electroretinogram (F-ERG).
Time frame: one day before injection, three months and six months after surgery
Change of the electrophysiological detection (electro-oculogram)
To evaluate the retinal function with the use of electro-oculogram (EOG)
Time frame: one day before injection, three months and six months after surgery
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