Precise identification of the infarct scar is essential for successful catheter ablation of ventricular arrhythmias in patients with chronic myocardial infarction. Voltage mapping of endocardial electrograms is currently used to delineate the necrotic scar but this is influenced by the direction of the activation wave front and is not sensitive enough to differentiate distinct degrees of transmural injury in the scar. Mapping of local myocardial electrical impedance may overcome these limitations.
Clinical series: Patients with chronic infarction undergoing catheter ablation of ventricular arrhythmias will be submitted to mapping of both voltage and tissue impedance. Likewise, the accuracy of the two maps identifying the extent and transmurality of the infarction will be assesssed by gadolinium imaging. The impedance system is already constructed and certified for clinical research use.
Study Type
OBSERVATIONAL
Enrollment
25
Patients will be submitted to mapping of both voltage and tissue impedance. The accuracy of the two maps identifying the extent and transmurality of the infarction will be assesssed by gadolinium imaging.
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
RECRUITINGComparative detection of infarct scar by voltage mapping
Voltage will be measured at different sites of the infarct scar and healthy tissue.
Time frame: 3 hours
Comparative detection of infarct scar by impedance mapping
myocardial local impedance will be measured at different sites of the infarct scar and healthy tissue.
Time frame: 3 hours
Comparative detection of infarct scar by gadolinium enhanced MR imaging
Intensity of gadolinium will be measured at different sites of the infarct scar and healthy tissue.
Time frame: 30 minutes
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