Characteristics of Different Types of Safety Lancets on Blood Volume and Perceived Pain in Male and Female Volunteers

HTL-Strefa S.A.100 enrolled

Overview

The study was a randomized, single blind, uni-center pivotal study in male and female healthy volunteers, to determine capillary blood volume and pain perception obtained in a process of puncturing with different safety lancets. A group of one hundred (100) healthy Caucasian male and female Subjects (aged \> 18 to \< 65 years old was randomized ) who were in good physical and mental condition. The Subjects had 4 (four) fingers (two fingers from each hand) lanced each with a different type of safety lancet. Overall, 4 (four) different safety lancets were investigated per each Subject. Overall, 16 (sixteen) different safety lancets (4 different safety lancets per one Subject) were investigated, the capillary blood volume and pain were measured.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

100

Conditions

Healthy

Interventions

Finger lancing was undertaken in a standardized way and was performed by medical staff trained from lancing procedure described in the Protocol. Total blood collection time was recorded in the source documentation and then volume of the blood was measured using a calibrated ruler. Perceived pain was assessed on the visual analog scale (VAS, numeric scale). VAS scale was assessed 5 minutes after the lancing procedure.

Acti-Lance UniversalDEVICE

Acti-Lance SpecialDEVICE

Medlance Plus Super LiteDEVICE

Medlance Plus LiteDEVICE

Medlance Plus UniversalDEVICE

Medlance Plus ExtraDEVICE

Medlance Plus SpecialDEVICE

Prolance Micro FlowDEVICE

Prolance Low FlowDEVICE

Prolance Normal FlowDEVICE

Prolance High FlowDEVICE

Prolance Max FlowDEVICE

Prolance PediatricDEVICE

MediSafe Solo 29 GaugeDEVICE

MediSafe Solo 23 GaugeDEVICE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Willing to sign the informed consent. * Male and female volunteers. * Age between 18 and 65 inclusive. * Able to communicate well with the Investigator and comply with the requirements of the study. * Volunteers who are in good physical and mental health. Exclusion Criteria: * Pregnancy or breastfeeding (self-reported). * Confirmed or suspected malignant cancer History of poor blood circulation. * Any skin condition on his or her fingers that prevents blood sampling. * Anxiety with needles or finger pricks. * Clotting disorders (including bleeding) in medical history. * Neuropathy or other condition affecting sensation in the hands. * History of blood borne infection (e.g., HIV, hepatitis B or C, syphilis, malaria, babesiosis, brucellosis, leptospirosis, arboviral infections, relapsing fever, T lymphotropic virus Type 1, Creutzfeldt-Jakob disease). * Currently participating in another study. * History of drug or alcohol abuse within the 12 months prior to screening or evidence of such abuse. * Intake of alcohol within 48 hours prior to the start of the study (self-reporting). * Donation or loss of 400 mL or more of blood within 4 weeks prior to the start of the study. * Any other condition that in the Investigator opinion may negatively influence Subject's participation in the study. * Intake of medicines that affect blood coagulability (including anticoagulants such as vitamin K, antivirals and anticoagulants such as heparin, aspirin, thrombin inhibitors, vitamin K antagonists).

Outcomes

Primary Outcomes

Volume (microliters) of blood in the capillary tube

The amount of capillary blood volume collected after a single lancing of the fingertip.

Time frame: The blood from the puncture site was collected to the capillaries by pressing during 2 minutes

Secondary Outcomes

Pain perception: VAS

The intensity of pain perceived by the patient was assessed with the use of the numeric Visual Analog Scale (VAS). The Subject marked on the scale the number from 0 ("no pain") to 10 ("worst imaginable pain") that represented their perception of pain. A higher score indicated greater pain intensity.

Time frame: 5 minutes after lancing