To assess the acute and long-term efficacy of half-normal saline compared to normal saline for irrigation of open-irrigated catheters during catheter ablation for the treatment of cavotricuspid isthmus dependent atrial flutter.
It is unclear whether ionic strength affects energy delivery and ablation lesion size during radiofrequency ablation for atrial flutter. Given that saline contains ionic sodium and chloride in the solution, it has conductive properties that may disperse radiofrequency energy away from the tip-tissue interface, thereby reducing current density and lesion size compared to ablation with nonionic solutions. The efficacy of half-normal saline will be measured by the time taken to create bidirectional block across the cavotricuspid isthmus as well as the acute recurrence rate within 30 minutes of the initial occurrence of bidirectional block and the 1 year freedom from flutter recurrence.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
4
Randomization to half normal saline
Randomization to normal saline
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
Time taken to produce bidirectional block
Time frame: intraprocedural
Acute recurrence rate < 30 minutes of initial occurrence of bidirectional block
Time frame: intraprocedural
Freedom from atrial flutter recurrence
Time frame: 1 year
Time taken for termination of atrial flutter
Time frame: intraprocedural
Total radiofrequency ablation time and procedural time
Time frame: intraprocedural
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