A strength and endurance training program was conducted in adults with myotonic dystrophy type 1 (DM1). Participants underwent a 12-week/18-session supervised training program consisted of 6 exercises: elbow flexion/extension, shoulder horizontal adduction, leg press, and knee flexion/extension. To offer a complete training program aimed at improving function it was divided: the first 6 weeks were dedicated to strength-training, whereas the following weeks focused on endurance-training. To evaluate the effects of the training program, participants completed maximal strength, endurance and functional evaluations. Volunteers could also add a muscle biopsy at the beginning and the end of the program to evaluate physiological parameters.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
11
12-week, 18-session training program. To offer a complete training program aimed at improving function it was divided : the first 6 weeks were dedicated to strength-training (2 sets of 6 repetitions at 80% of 1-RM), whereas the following weeks focused on endurance-training (1 set of 25 repetitions at 40% of 1-RM).
Groupe de recherche interdisciplinaire sur les maladies neuromusculaires
Saguenay, Quebec, Canada
Change in maximal muscle strength in the knee extensors measured by quantified muscle testing
Changes in knee extensor maximal muscle strength evaluated by quantified muscle testing with a handheld dynamometer.
Time frame: Before and after the 12-week training program
Change in 6 minute walking test disance
Walking endurance change measured by the 6 minute walking test distance.
Time frame: Before and after the 12-week training program
Changes in functional capacity measured by the UQAM-YMCA test
Functional capacity evaluated by 18 functional tests
Time frame: Before and after the 12-week training program
Changes in sprint capacity measured by the Running-base anaerobic sprint test
Sprint capacity changes measured by the running-base anaerobic sprint test
Time frame: Before and after the 12-week training program
Changes in fatigue measured by the Fatigue severity scale
Fatigue questionnaire: 9-item questionnaire rated on a scale from 1 to 7 for each item. A score a higher score means more fatigue.
Time frame: Before and after the 12-week training program
Changes in daytime sleepiness measured by the Daytime sleepiness scale (Epworth Sleepiness Scale)
8-item questionnaire, rated on a scale from 0 to 3 for each item, the higher the score, the more the patient has daytime sleepiness.
Time frame: Before and after the 12-week training program
Changes in stumbles and falls measured by the Falls efficacy scale
10-item questionnaire about stumbles and falls. All items are rated on a 10-point scale. A higher score means a higher fear of falling. A score over 70 means a significant fear of falling.
Time frame: Before and after the 12-week training program
Changes in quality of life measured by the 36-Item Short Form Survey (SF-36)
36-item quality of life questionnaire. The final score is calculated on a total of 100 where the lower the score, the more disability. A score of 100 means no disability.
Time frame: Before and after the 12-week training program
Changes in life habits measured by questionnaire
Life habits questionnaire Assessment of life habits is a 77-item questionnaire with a scale from 0 to 9 for each item. A higher score means no disability and a low score means more disability.
Time frame: Before and after the 12-week training program
Changes in muscle biopsy-muscle fiber size
To assess changes in muscle fiber size
Time frame: Before and after the 12-week training program for volunteers
Changes in muscle biopsy-muscle fiber typing
To assess changes in muscle fiber typing
Time frame: Before and after the 12-week training program for volunteers
Changes in muscle biopsy-proportion of centrally nuclated fibers
To assess changes in muscle centrally nucleated fibers proportion
Time frame: Before and after the 12-week training program for volunteers
Changes in muscle biopsy-leucocyte infiltration
To assess changes in muscle fiber leucocyte infiltration
Time frame: Before and after the 12-week training program for volunteers
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