Major Depression Disorder is one of the most common psychiatric disease and has affecting approximately 350 million people in the world. According to World Health Organization's report, it may be the first burden of disease in 2030. Due to the high morbidity and low acceptance in the treatment, it is necessary to find some nature compounds to prevent the disease. Cordyceps militaris, one of the most treasure Chinese herbs in Asia, contains many kinds of component such as cordycepin, polysaccharide, mannitol. In winter, it appears as an worm in the soil, afterwards, it grows out of the soil and convert into grass in summer. A previous study has demonstrated that Cordyceps militaris has anti-depressive effect in mouse tail suspension test, and in this study we will explore its effect in human subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
80
Subjects recruited from both arms will receive treatment and be followed up clinically for 8 weeks.
China Medical University Hospital
Taichung, Taiwan
Change of subjective depressive symptoms
Measured by Beck Depression Inventory-II
Time frame: 8 weeks
Change of objective depressive symptoms
Measured by Hamilton Rating Scale for Depression
Time frame: 8 weeks
Change of somatic symptoms
Measured by Neurotoxicity Rating Scale, a 39-item self-report scale to evaluate the somatic symptoms such as anorexia, fatigue and pain; higher scores indicate higher severity.
Time frame: 8 weeks
Cortisol level
Measured as a stress-related biomarker
Time frame: 8 weeks
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