The purpose of this study is to investigate the pharmacokinetics, safety, and tolerability of JNJ-73763989 in healthy Japanese adult participants following single-dose subcutaneous administration of 3 different doses of JNJ-73763989, Dose Level 1 (Panel A), Dose Level 2 (Panel B) or Dose Level 3 (Panel C).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
25
Participants will receive JNJ-73763989 as single subcutaneous injection.
Participants will receive placebo matching to JNJ-73763989 as single subcutaneous injection.
PAREXEL International
London, United Kingdom
Maximum Observed Plasma Concentration (Cmax) of JNJ-73763989
Cmax is the maximum observed plasma analyte concentration.
Time frame: Predose, 0.25, 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, and 48 hours postdose
Time to Reach Maximum Observed Plasma Concentration (Tmax) of JNJ-73763989
Tmax is defined as actual sampling time to reach maximum observed plasma analyte concentration.
Time frame: Predose, 0.25, 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, and 48 hours postdose
Last Measurable Observed Plasma Concentration (Clast) of JNJ-73763989
Clast is last measurable observed plasma analyte concentration.
Time frame: Predose, 0.25, 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, and 48 hours postdose
Area Under the Plasma Concentration-Time Curve from Time Zero to the Time of the Last Measurable Concentration (AUC[0-last]) of JNJ-73763989
AUC(0-last) is area under the plasma concentration-time curve from time zero to the time of the last measurable (non-below quantification limit \[non-BQL\]) concentration, calculated by linear-linear trapezoidal summation.
Time frame: Predose, 0.25, 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, and 48 hours postdose
Number of Participants with Adverse Events (AEs) as a Measure of Safety and Tolerability
AE is any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship.
Time frame: Up to 30 days after last study drug administration (Up to 7 weeks)
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