Human BCMA Targeted T Cells Injection Therapy for BCMA-positive Relapsed/Refractory Multiple Myeloma

Inclusion Criteria: 1. Subjects volunteer to participate in clinical research, understand and know the research and sign informed consent document, willing to complete all the trial procedures; 2. 18 to 70 Years Old, Male and female; 3. Expected survival \> 12 weeks; 4. Previously diagnosed as multiple myeloma by IMWG updated criteria (2014); 5. Patients with positive pathological test results or flow cytometry proving that BCMA expression of malignant plasma cells in bone marrow or plasma cell tumors ≥30%; 6. One of the following indicators is satisfied: 1. Serum M protein IgG ≥ 10 g/L, or IgA \> 10 mg/L, or IgD \> 5 mg/L; 2. Urine M protein ≥ 200 mg/24h; 3. Serum free light chain ≥ 100 mg/L; 7. Patients with relapsed/refractory multiple myeloma. Relapsed is defined as: Patients have disease progression after at least three-line treatment regimens. Patients previously received at least 3 different mechanisms treatment regimens for multiple myeloma, including protease inhibitors and immunomodulators, and have disease progression within 60 days of the latest treatment ; Refractory is defined as: Patients who achieved remission in the piror therapies, have disease progression within 60 days, or after the latest therapy. 8. Those who relapse 90 days after stem cell transplantation 9. ECOG score 0-1; 10. Liver, kidney and cardiopulmonary functions meet the following requirements: 1. Creatinine clearance (estimated by Cockcroft Gault formula) ≥ 40 mL/min; 2. Left ventricular ejection fraction \>50%; 3. Baseline peripheral oxygen saturation \>95%; 4. Total bilirubin ≤ 2×ULN; ALT and AST ≤2.5 × ULN; 11. The venous access required for collection can be established, and no leukocyte collection contraindications. Exclusion Criteria: 1. Accompanied by other uncontrolled malignancies; 2. Subjects with positive HBsAg or HBcAb and peripheral blood HBV DNA titer is higher than the lower limit of detection of the research institution; HCV antibody positive and peripheral blood HCV RNA positive; HIV antibody positive; syphilis primary screening antibody positive; 3. Any instability of systemic disease, including but not limited to unstable angina, cerebrovascular accident, or transient cerebral ischemic (within 6 months prior to screening), myocardial infarction (within 6 months prior to screening), congestive heart failure (New York heart association (NYHA) classification ≥ III), severe arrhythmia, liver, kidney or metabolic disease with poor drug control; 4. Patients who are accounted to be not appropriate for this trail by investigator; 5. Pregnant or lactating, or planning to have a pregnancy during or within 1 year after treatment; 6. Received CAR-T treatment or other gene therapies before enrollment; 7. Those who failed to sign informed consent form or comply with the research procedures; Unwilling or unable to comply with research requirements; 8. Have had severe immediate hypersensitivity reactions to any drugs used in this research; 9. The presence or suspicion of fungi, bacteria, viruses or other infections that are uncontrollable or requiring intravenous treatment; 10. In the past two years, the terminal organ was damaged due to autoimmune diseases (such as crohn's disease, rheumatoid arthritis, systemic lupus erythematosus), or the systemic use of immunosuppressive or other systemic disease control drugs was required; 11. Have a history of central nervous system (CNS) disease, such as epilepsy, seizures, paralysis, aphasia, stroke, severe brain damage, dementia, Parkinson's disease, psychosis.