Effects of High Flow Nasal Cannula on Breathing and the Respiratory System Parameters

Czech Technical University in Prague12 enrolled

Overview

The aim of this study is a detailed investigation of the effect of High Flow Nasal Oxygenation (HFNO) on respiratory system characteristics and ventilation parameters in healthy adult subjects and the subsequent use of measured data to answer the following questions: What level of positive end expiratory pressure (PEEP) causes a HFNO with different flow rates? Does HFNO work as pressure support or does it act more like a Continuous Positive Airway Pressure (CPAP) ventilation?

High Flow Oxygen through nasal cannula is widely used in the setting of hypoxemic respiratory failure of heterogenous etiology with very good patients compliance. However, the evidence of what level of PEEP or pressure support (if any) with different flow rates is weak. Our goal is to determine these effects and compare them with standard approach with non-invasive ventilation via full face mask.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

High Flow Nasal generator (AirVO2)DEVICE

High Flow Nasal Oxygenation

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy volunteers willing to participate Exclusion Criteria: * general contraindications for oesophageal catheter insertion: oesophageal varices, bleeding disorders (including anticoagulant medication), diverticulitis, oesophageal tumors, history of recent oesophageal/gastric surgery, recent epistaxis, * sinusitis * allergy to local anesthetics * subject refusal

Locations (1)

Czech Technical University in Prague

Kladno, Czechia

Outcomes

Primary Outcomes

Measurement of inspiratory pressure, pressure in a hypopharynx and pleural pressure estimation using oesophageal catheter on conventional non-invasive ventilation (NIV).

Using measurement of several pressures - inspiratory, oesophageal, nasopharyngeal (cm of H20 on conventional NIV.

Time frame: 1 hour

Measurement of inspiratory pressure, pressure in a hypopharynx and pleural pressure estimation using oesophageal catheter on High flow nasal oxygenation (HFNO).

Using measurement of several pressures - inspiratory, oesophageal, nasopharyngeal (cm of H20) on High flow nasal oxygenation (HFNO).

Time frame: 1 hour

Calculation of Pressure Time Product (PTP) for estimation of Work of Breathing (WOB).

Compare PTP between conventional NIV and HFNO.

Time frame: up to 8 weeks

Monitoring of EIT during spontaneous ventilation on conventional non-invasive ventilation (NIV).

EIT for description of distribution of ventilation on conventional NIV at different levels of PEEP (cm H20).

Time frame: 1 hour

Monitoring of EIT during spontaneous ventilation with High flow nasal oxygenation (HFNO).

EIT for description of distribution of ventilation with HFNO with different flow rate levels (litres per minute).

Time frame: 1 hour

Data from ClinicalTrials.gov

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