Use of Infrared Spectroscopy in Fast Septic Arthritis Diagnosis

Rennes University Hospital360 enrolled

Overview

To study the diagnostic performance of infrared spectroscopy on fresh synovial fluids in early septic arthritis diagnosis in patients with acute joint effusion

Diagnosis of a joint effusion is frequently a medical emergency, especially when septic arthritis is suspected. Septic arthritis diagnosis relies on microscopic and bacteriological analysis of synovial fluid obtained by arthrocentesis. Direct microscopic examination can be made within 2 to 12 hours but it is negative in about 50 % of the cases. It is necessary to wait 72 hours to obtain the result of the culture and reasonably rule out the diagnosis of septic arthritis. A method of establishing an immediate etiological diagnosis could improve the care of patients with joint effusion that is a therapeutic emergency and justify a hospitalization and a parenteral antibiotic therapy.

Study Type

OBSERVATIONAL

Enrollment

360

Conditions

Joint Effusion

Interventions

Infrared spectroscopyDEVICE

Infrared spectroscopy

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients over 18 year old * patients with an acute arthritis defined by an evolution of less than 6 weeks * patients benefiting from joint fluid puncture for diagnostic purposes in the rheumatology hospitals participating in the study * patients who received information about the protocol and have not expressed opposition to participate Exclusion Criteria: * patients opposing the study * protected major (safeguard justice, trusteeship and guardianship) and persons deprived of liberty

Locations (6)

CHU Angers

Angers, France

CHRU Brest

Brest, France

CHU Clermont-Ferrand

Clermont-Ferrand, France

CHU Nantes

Nantes, France

CHU de Rennes

Outcomes

Primary Outcomes

Diagnosis of the cause of joint effusion

The final diagnosis of the cause of joint effusion is made by the clinician based on the clinical and laboratory data : septic arthritis or other causes of arthritis

Time frame: Up to 7 days (time to perform Spectroscopy and collect laboratory results)

Secondary Outcomes

Number of days of hospitalization

The clinician will be asked to state how a positive or a negative result of the diagnostic test under study would have affected his decision to hospitalize the patient

Time frame: Up to 2 months (time to collect data on hospitalization duration and antibiotic therapy duration)

Total dose of antibiotics

The clinician will be asked to state how a positive or a negative result of the diagnostic test under study would have affected his decision to start antibiotic therapy

Time frame: Up to 2 months (time to collect data on hospitalization duration and antibiotic therapy duration)

Data from ClinicalTrials.gov

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