Ketamine Infusion for Sickle Cell Pain Crisis

Inclusion Criteria: * Have a pre-existing/known diagnosis of sickle cell disease, prior to the current presentation * Admitted to Duke University Hospital with a clinical diagnosis of sickle cell crisis * Are at least 18 years old at time of admission * Have been admitted to any hospital for sickle cell pain crisis at least twice in the last year * Have documented severe pain at time of admission, requiring intravenous opiates * Must be able to speak English Exclusion Criteria: * Are greater than 70 years old at time of admission * Carry a diagnosis of cirrhosis, elevated intracranial pressure, elevated intraocular pressure, active coronary artery disease, and psychiatric disorders with history of psychosis * Are pregnant or breastfeeding * Are concomitantly admitted for another medical or surgical problem in addition to sickle cell pain crisis * Have been admitted to any hospital for a sickle cell pain crisis greater than 10 times in the last year * Were admitted to any hospital for sickle cell pain crisis within the last 30 days * Are able to fully and properly consent for their own medical care, with no restrictions or limitations