The primary objective of this study is to assess the pharmacokinetics of a single oral dose of apixaban (5mg) in participants with dialysis peritoneal versus participants with normal renal function.
Participants with chronic renal disease treated with peritoneal dialysis and participants with normal renal function are hospitalized for three days.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
24
Apixaban oral single dose 5mg
CHU Caen
Caen, France
Apixaban area Under the curve
Measurement of apixaban plasma concentrations at different times.
Time frame: Day 3
Apixaban maximum plasma concentration
Measurement of apixaban plasma concentrations at different times.
Time frame: Day 3
anti-Xa activity
anti-Xa activity plasma measurements
Time frame: Hour 0, Hour 3, Hour 9 and Hour 72
TP activity
TP activity plasma measurements
Time frame: Hour 0, Hour 3, Hour 9 and Hour 72
TCA activity
TCA activity plasma measurements
Time frame: Hour 0, Hour 3, Hour 9 and Hour 72
Apixaban urinary elimination
Measurement of apixaban urinary concentrations
Time frame: Day 3
Apixaban maximum peritoneal concentration
Measurement of apixaban peritoneal fluid concentrations
Time frame: day 3
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