A Registered Cohort Study on Spastic Paraplegia

Wan-Jin Chen500 enrolled

Overview

The aim of this study is to determine the clinical spectrum and natural progression of Hereditary Spastic Paraplegias(HSP) and related disorders in a prospective multicenter natural history study, to assess the clinical, genetic and epigenetic features of patients with Spastic Paraplegias to optimize clinicalmanagement..

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Spastic Paraplegia

Interventions

OTHER

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with the clinical diagnosis of spastic paraplegia * Clinical diagnosis of patients with spastic paraplegia * Unrelated healthy controls Exclusion Criteria: * Decline to participate. * There are serious interferences with individual participation and adherence to the research protocol, including but not limited to neurological, psychological, and/or medical conditions.

Locations (1)

First Affiliated Hospital Fujian Medical University

Fuzhou, China

RECRUITING

Outcomes

Primary Outcomes

Spastic Paraplegia Rating Scale (SPRS)

Disease severity will be assessed by application of the Spastic Paraplegia Rating Scale (SPRS), a clinical rating scale measuring disease severity in Hereditary Spastic Paraplegia (Schule et al. Neurology 2006). The SPRS contains 13 items, each ranging from 0 to 4 points. The total score is calculated as the sum of all items, yielding a range for the total score between 0 and 52. Hereby, higher SPRS total scores indicate more severe disease.

Time frame: 6 months

Central Contacts

Yi Lin, MD,PhD

CONTACT

+13615039153 wanjinchen75@fjmu.edu.cn

Wan-Jin Chen, MD,PhD

CONTACT

+1386061359 wanjinchen75@fjmu.edu.cn

Data from ClinicalTrials.gov

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