Meta-analysis of Stannous Fluoride and the Effects on Enamel Erosion

Procter and Gamble172 enrolled

Overview

The aim of this 5 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) dentifrices to assess enamel erosion protection in-situ using surface profilometry.

Study Type

OBSERVATIONAL

Enrollment

172

Conditions

Enamel Erosion

Interventions

Stannous fluoride dentifriceDRUG

Stannous fluoride (0.454%) dentifrice

Positive control dentifriceDRUG

Positive control dentifrice containing potassium nitrate or arginine.

Negative control dentifriceDRUG

Negative control dentifrice containing either sodium fluoride (0.243%) or sodium monofluorophosphate (0.76%)

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy subjects

Locations (1)

Multiple P&G Investigation Clinical Sites

Cincinnati, Ohio, United States

Outcomes

Primary Outcomes

Change from Baseline Surface profilometry

Enamel samples will be measured via profilometry after 10 days of study use.

Time frame: 10 days

Data from ClinicalTrials.gov

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