Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque

Procter and Gamble2,359 enrolled

Overview

The aim of this 18 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) dentifrices when used up to 3 months on dental plaque relative to a positive or negative control dentifrice.

Study Type

OBSERVATIONAL

Enrollment

2,359

Conditions

Dental Plaque

Interventions

Stannous fluoride dentifriceDRUG

Stannous fluoride (0.454%) dentifrice

Positive control dentifriceDRUG

Positive control dentifrice containing (0.3%) triclosan.

Negative control dentifriceDRUG

Negative control dentifrice containing either sodium fluoride (0.243%) or sodium monofluorophosphate (0.76%)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Subjects were excluded from this study for the following reasons; * pregnancy, * rampant caries, * severe periodontitis, * at discretionary of the Principal Investigator.

Locations (1)

Multiple P&G Investigation Clinical Sites

Cincinnati, Ohio, United States

Outcomes

Primary Outcomes

Dental Plaque Scores

Change from baseline as measured by mean plaque score reduction from baseline (via Quigley-Hein, Turesky Modification Index or Rustogi Modification of the Navy Plaque index).

Time frame: Up to 12 weeks

Data from ClinicalTrials.gov

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