Glaucoma represents a group of conditions that cause damage to the optic nerve and can lead to irreversible vision loss. Current treatments are aimed at lowering intraocular pressure while minimizing medication side effects. Lumify™ (Brimonidine Tartrate Ophthalmic Solution 0.025%) is an FDA-approved medication for alleviating eye redness, a common side effect of glaucoma medications. The purpose of this study is to evaluate the effect of Lumify™ on eye redness, intraocular pressure, and eyelid position in patients with glaucoma who are already using the Brimonidine 0.1%, 0.15% or 0.2% eye drops.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
60
Single dose of brimonidine tartrate ophthalmic solution 0.025% applied as an eye drop to the eye surface.
Single dose of sterile balanced saline solution applied as an eye drop to the eye surface.
Tulane University Medical Center
New Orleans, Louisiana, United States
Ocular redness
Scoring of ocular redness on clinical photographs using the the Investigator Ocular Redness Scale (0-4; 0 = no ocular redness, 4 = extremely severe ocular redness)
Time frame: 5 minutes after application of eye drop
Ocular redness
Scoring of ocular redness on clinical photographs using the the Investigator Ocular Redness Scale (0-4; 0 = no ocular redness, 4 = extremely severe ocular redness)
Time frame: 15 minutes after application of eye drop
Ocular redness
Scoring of ocular redness on clinical photographs using the the Investigator Ocular Redness Scale (0-4; 0 = no ocular redness, 4 = extremely severe ocular redness)
Time frame: 30 minutes after application of eye drop
Ocular redness
Scoring of ocular redness on clinical photographs using the the Investigator Ocular Redness Scale (0-4; 0 = no ocular redness, 4 = extremely severe ocular redness)
Time frame: 60 minutes after application of eye drop
Intraocular pressure
Measurement of intraocular pressure using handheld tonometer (TonoPen)
Time frame: 60 minutes after application of eye drop
Palpebral fissure height
Measurement of distance between inner margin of upper and lower eyelids from clinical photographs
Time frame: 60 minutes after application of eye drop
Eye discomfort
Subjective scoring of ocular discomfort by patient on a 0-10 unit scale (0 = very comfortable, 10 = very uncomfortable)
Time frame: 60 minutes after application of eye drop
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