Effect of Dexmedetomidine on the Inflammatory Response After One-lung Ventilation

Seoul St. Mary's Hospital40 enrolled

Overview

The postoperative inflammatory response is significant in lung resection surgery because of major operation and one-lung ventilation. Dexmedetomidine has been shown to reduce pro-inflammatory cytokine levels and improve clinical outcomes. The aim of this study was to determine the effects of dexmedetomidine on inflammatory responses after lung resection surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Lung Cancer

Interventions

DexmedetomidineDRUG

The study drug for each group was administered from the time immediately after induction of anesthesia until the end of the surgery.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * elective video-assisted thoracoscopic surgery (VATS) lobectomy * 20 \< age \< 75 * American Society of Anesthesiologists (ASA) classification I\~II Exclusion Criteria: * preoperative inflammation (CRP\>10ng/#, WBC\>10,000/mm3, body temperature \>38#) * steroid administration within 1 month * hematologic / autoimmune disease * congestive heart failure (NYHA class III\~IV) or significant arrhythmia * severe obstructive / restrictive pulmonary disease * previous history of thoracic surgery

Locations (1)

Seoul St.Mary's Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Interleukin (IL)-6

Blood samples were collected from the antecubital vein

Time frame: 24 hours after surgery

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.