Inflammatory Response After One-lung Ventilation According to Ventilation Methods

Seoul St. Mary's Hospital40 enrolled

Overview

Unlike conventional thoracic surgery performed under general anesthesia with tracheal intubation, non-intubated thoracic surgery with sedation and regional anesthesia has been performed recently. Non-intubated thoracic surgery is expected to reduce the postoperative inflammatory changes by maintaining more physiologic status during the operation compared to intubated thoracic surgery. The aim of this study was to compare perioperative immunological changes between intubated and non-intubated thoracic surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Lung Cancer

Interventions

Ventilation methodOTHER

Depending on the group assignment, mechanical ventilation or spontaneous breathing was performed.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * elective video-assisted thoracoscopic surgery (VATS) lobectomy * 20 \< age \< 75 * American Society of Anesthesiologists (ASA) classification I\~II Exclusion Criteria: * preoperative inflammation (CRP\>10ng/㎖, WBC\>10,000/mm3, body temperature \>38℃) * steroid administration within 1 month * hematologic / autoimmune disease * congestive heart failure (NYHA class III\~IV) or significant arrhythmia * severe obstructive / restrictive pulmonary disease * previous history of thoracic surgery * BMI \>28kg/m2 * expected difficult airway

Locations (1)

Seoul St.Mary's Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Interleukin (IL)-6

Blood samples collected from the antecubital vein

Time frame: 24 hours after surgery

Data from ClinicalTrials.gov

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