Anti-CD22 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy for Relapsed Refractory B-cell Malignancies

Inclusion Criteria: 1. Patient or his or her legal guardian voluntarily participates in and signs an informed consent form. 2. Male or female patients aged 14 to 70 years (including 14 and 70 years old). 3. Pathological and histological examination confirmed CD22+ B-cell malignancies, and patients met the following criteria for refractory or relapsed B-cell malignancies. A.Refractory/relapsed B-cell lymphoblastic leukemia (Meeting one of the following) i. Recurrence within 6 months after first remission. ii. Primary refractory disease which cannnot achieve complete remission (CR) after 2 cycles of standardized chemotherapy regimen. iii. Failure to achieve CR or relapse after one line or multiple lines of salvage chemotherapy. iv. Not suitable for hematopoietic stem cell transplantation (HSCT), or abandon HSCT due to various restrictions, or relapse after HSCT. B.Refractory/relapsed B-cell lymphoma (Meeting 1 of the first 4 items plus item 5) i. Tumor shrinkage less than 50% or disease progression after 4 cycles of standard chemotherapy. ii. Achieved CR after standard chemotherapy, but relapsed within 6 months. iii. 2 or more relapses after CR. iv. Not suitable for HSCT, or abandon HSCT due to various restrictions, or relapse after HSCT. v. Subjects must have received adequate treatment in the past, including anti-CD20 monoclonal antibody and combination chemotherapy with anthracyclines. 4. B-cell malignancies include the following three types A. B-cell acute lymphoblastic leukemia (B-ALL) B. Indolent B-cell lymphoma (CLL, FL, MZL, LPL, HCL) C. Invasive B-cell lymphoma (DLBCL, BL, MCL) 5. Having a measurable or evaluable lesion A. Patients with lymphoma require a single lesion≥15mm or 2 or more lesions≥10mm. B. Patients with leukemia require persistent positive or positive relapse of bone marrow MRD. 6. Patient's main organs functioning well A. Liver function: ALT/AST \< 3 times the upper limit of normal (ULN) and total bilirubin≤34.2μmol/L B. Renal function: Creatinine \< 220μmol/L. C. Pulmonary function: Indoor oxygen saturation≥95%. D. Cardiac Function: Left ventricular ejection fraction (LVEF) ≥40%. 7. The patients did not receive any antitumor treatments such as chemotherapy, radiotherapy and immunotherapy (such as immunosuppressive drugs) within 4 weeks before enrollment, and the toxicity related to previous treatments had returned to \< 1 level at enrollment (except for low grade toxicity such as alopecia). 8. The patient's peripheral superficial venous blood flow smoothly, which can meet the needs of intravenous drip. 9. Patient ECOG score≤ 2, estimated survival time≥3 months. Exclusion Criteria: 1. Have a history of epilepsy or other central nervous system diseases. 2. Women who are pregnant (urine/blood pregnancy test positive) or lactating. 3. Male or female with a pregnancy plan in the next 1 year. 4. Patients cannot guarantee effective contraception (condom or contraceptives, etc.) within 1 year after enrollment. 5. Uncontrolled infectious disease within 4 weeks prior to enrollment. 6. Active hepatitis B/C virus infection. 7. HIV infected patients. 8. Suffering from a serious autoimmune disease or immunodeficiency disease. 9. The patient is allergic to macromolecular biopharmaceuticals such as antibodies or cytokines. 10. The patient participated in other clinical trials within 6 weeks prior to enrollment. 11. Systemic use of corticosteroids within 4 weeks prior to enrollment (except for patients with inhaled corticosteroids). 12. Suffering from mental diseases. 13. Patient has drug abuse/addiction. 14. According to the researcher's judgment, the patient has other unsuitable enrollment conditions.