Hepcidin and Glucose Metabolism

Swiss Federal Institute of Technology30 enrolled

Overview

Gestational diabetes mellitus (GDM), defined as hyperglycemia with blood glucose values above normal but below those diagnostic of DM, and iron deficiency (ID) with or without anemia (IDA) are common during pregnancy. Both disease patterns are associated with an increased risk of complications during pregnancy and at delivery and may have a variety of negative effects on different aspects of child development. Thus, GDM and ID/IDA during pregnancy should be prevented. Whether iron supplementation with high oral doses acutely increases hepcidin during pregnancy, and whether this acute iron-induced increase in hepcidin decreases insulin sensitivity, is uncertain.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Iron Deficiency Anemia of Pregnancy Iron Metabolism Disorders Glucose Intolerance Gestational Diabetes

Interventions

100mg iron fumarateDIETARY_SUPPLEMENT

100mg iron fumarate b.i.d. for 4 consecutive days

Burgerstein Schwangerschaft & StillzeitDIETARY_SUPPLEMENT

contains 30 mg iron fumarate, given on 14 consecutive days

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * week of pregnancy 24-28 * pre-pregnancy BMI \<27.5kg/m2 * singleton pregnancy * Hb \> 8.0 g/dl Willing to either: * not take any iron supplements for 14 days (however, participants will receive a similar amount of total iron during the 4 study days that they would normally receive over 14 days) OR * to take the multivitamin "Burgerstein Schwangerschaft and Stillzeit" supplements over the 14 days (contains 30 mg iron) Exclusion Criteria: * iron infusion within the past 6 months * severely anemic Hb\<8.0g/dl * acute or chronic disease * long-term medication * medical problems known to affect iron homeostasis * smoking

Locations (1)

Human Nutrition Laboratory ETH Zurich

Zurich, Switzerland

RECRUITING

Outcomes

Primary Outcomes

Serum hepcidin

Time frame: before OGTT, 1 day before high/low iron supplementation

Serum hepcidin

Time frame: after OGTT, 1 day before high/low iron supplementation

Serum hepcidin

Time frame: before OGTT, after high/low iron supplementation at day 7

Serum hepcidin

Time frame: after OGTT, after high/low iron supplementation at day 7

Serum iron

Time frame: before OGTT, 1 day before high/low iron supplementation

Serum iron

Time frame: after OGTT, 1 day before high/low iron supplementation

Serum iron

Time frame: before OGTT, after high/low iron supplementation at day 7

Serum iron

Time frame: after OGTT, after high/low iron supplementation at day 7

glucose

Time frame: before OGTT, 1 day before high/low iron supplementation

glucose

Time frame: after OGTT, 1 day before high/low iron supplementation

glucose

Time frame: before OGTT, after high/low iron supplementation at day 7

glucose

Time frame: after OGTT, after high/low iron supplementation at day 7

insulin

Time frame: before OGTT, 1 day before high/low iron supplementation

insulin

Time frame: after OGTT, 1 day before high/low iron supplementation

insulin

Time frame: before OGTT, after high/low iron supplementation at day 7

insulin

Time frame: after OGTT, after high/low iron supplementation at day 7

Serum hepcidin

Time frame: At day 14, 7 days after high iron supplementation and 1 day after low iron supplementation

Serum iron

Time frame: At day 14, 7 days after high iron supplementation and 1 day after low iron supplementation

glucose

Time frame: At day 14, 7 days after high iron supplementation and 1 day after low iron supplementation

insulin

Time frame: At day 14, 7 days after high iron supplementation and 1 day after low iron supplementation

Secondary Outcomes

Serum ferritin

Time frame: before OGTT, 1 day before high/low iron supplementation

Serum ferritin

Time frame: after OGTT, 1 day before high/low iron supplementation

Serum ferritin

Time frame: before OGTT, after high/low iron supplementation at day 7

Serum ferritin

Time frame: after OGTT, after high/low iron supplementation at day 7

soluble transferrin receptor

Time frame: before OGTT, 1 day before high/low iron supplementation

soluble transferrin receptor

Time frame: after OGTT, 1 day before high/low iron supplementation

soluble transferrin receptor

Time frame: before OGTT, after high/low iron supplementation at day 7

soluble transferrin receptor

Time frame: after OGTT, after high/low iron supplementation at day 7

c-reactive protein

Time frame: before OGTT, 1 day before high/low iron supplementation

c-reactive protein

Time frame: after OGTT, 1 day before high/low iron supplementation

c-reactive protein

Time frame: before OGTT, after high/low iron supplementation at day 7

c-reactive protein

Time frame: after OGTT, after high/low iron supplementation at day 7

Central Contacts

Nicole U Stoffel, PhD

CONTACT

+41 44 632 83 93 nicole.stoffel@hest.ethz.ch

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

Time frame: before OGTT, 1 day before high/low iron supplementation

alpha glycoprotein

Time frame: after OGTT, 1 day before high/low iron supplementation

alpha glycoprotein

Time frame: before OGTT, after high/low iron supplementation at day 7

alpha glycoprotein

Time frame: after OGTT, after high/low iron supplementation at day 7