Effect of Vitamin B12 on the Development of Sepsis, in Culture Positive Patients

University of Zurich100 enrolled

Overview

This is an prospective observational study assessing the effect of vitamin B12 on the odds of developing sepsis in patients with infection confirmed by a positive culture result. The hypothesis is that patients with infection confirmed by positive cultures who develop sepsis have lower vitamin B12 levels than patients infection, confirmed by positive cultures, who do not develop sepsis.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Bacteremia

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults (≥18 years old) * Infection, confirmed by a positive culture result * Signed informed consent. Exclusion Criteria: * Pregnancy and/or breast feeding * Inability to follow the procedures of the study, due to language problems, psychological disorders, social conditions or dementia

Locations (1)

University Hospital of Zurich

Zurich, Switzerland

Outcomes

Primary Outcomes

Holotranscobalamin (HTC) levels

HTC levels in patients with infection and sepsis compared to patients with infection without sepsis.

Time frame: 6 days

Secondary Outcomes

Vitamin B12 levels

Levels of vitamin B12 in patients with infection and sepsis compared to patients with infection without sepsis

Time frame: 6 days

Methylmalonic acid (MMA) levels

Levels of ethylmalonic acid (MMA) in patients with infection and sepsis compared to patients with infection without sepsis

Time frame: 6 days

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.