Meningitis, defined as inflammation of the meninges caused by different pathogens, is a serious infection associated with high morbidity and mortality. It occurs more commonly in the neonatal period than in any other age group. Neonatal meningitis is a devastating infection that occurs more commonly in neonates than in any other age group, and is associated with significant morbidity and mortality. In this study, we aimed to evaluate epidemiology, treatment and prognosis of neonatal meningitis in a large-scale retrospective multicenter cohort study. The main objectives of this study were to assess the incidence, temporal trend, risk factors, causative organisms, and short term outcomes of neonatal meningitis in a large national cohort of newborn infants admitted to Turkey NICUs.
Study Type
OBSERVATIONAL
Enrollment
500
Zekai Tahir Burak Women's Health Research and Education Hospital
Ankara, Turkey (Türkiye)
RECRUITINGBursa Yuksek Ihtisas Research and Education Hospital
Bursa, Turkey (Türkiye)
RECRUITINGGazi Yasargil Education Research Hospital
Diyarbakır, Turkey (Türkiye)
RECRUITINGİstanbul Kanuni Sultan Süleyman Training and Research Hospital
Istanbul, Turkey (Türkiye)
RECRUITINGIzmir Katip Celebi University, Medical Faculty
Izmir, Turkey (Türkiye)
RECRUITINGIncidence of neonatal meningitis
Occurrence of a meningitis in NICU within a specified period of time. (Number of neonatal meningitis cases / Total number of inpatients in the study period)
Time frame: average of 5 years
Causative organisms
Number and types of isolated microorganisms in CSF cultures
Time frame: average of 5 years
Neurodevelopmental Outcome
\- Bayley Scales of Infant Development, Second Edition (BSID II), was performed a comprehensive assessment including neurological and developmental evaluation. The mean BSID II score is 100 for Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI), with a standard deviation (SD) of 15; a score of less than 70 (42 SDs below the mean) indicates a significant delay. Infants who were so severely impaired that testing with the BSID II could not be performed were assigned a MDI and PDI score of 49.
Time frame: 18 to 24 months
Mortality
Neonatal meningitis related mortality
Time frame: up to 28 days
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