Music has been consistently shown magic power in brain plasticity. Several study proved music can influence electronic activity of preterm infants' brain, while none study covered region oxygen metabolic. The investigators aim to discover the effects of music therapy on near-infrared spectroscopy and electroencephalogram in premature infants.
Previous studies of music therapy have made some achievements for adult Parkinson's disease, schizophrenia, depression, anxiety, post-traumatic stress and pediatric autism spectrum disorders. For newborns, studies mainly focused on the effects of basic vital signs, feeding and pain score decreasing. So far, no studies evaluating the effect of music therapy on brain oxygen metabolic and electronic activity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
45
music selected by musician
Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, China
change of brain oxygen saturation
near-infrared spectroscopy to monitor brain oxygen saturation
Time frame: from the start of the intervention to the end of the 3rd day
Burdjalov Scores of amplitude integrated electroencephalogram
electroencephalogram to monitor brain electronic activity, using Burdjalov developed cerebral function monitoring scoring system which including: (1)record continuity: assessed through observing the overall density of the sample tracing, scores ranged from 0 to 2；(2) presence of cyclic changes：refers to the emergence and progression of periods during monitoring，scores ranged from 0 to 5；（3）degree of voltage amplitude depression：estimated as the average lower microvolt level during the recording epoch ，scores ranged from 0 to 2；（4）bandwidth：reflects a combination of the voltage span (peak-to-trough) of the tracing and the magnitude of the electroencephalogram depression，scores ranged from 0 to 4. The minimum possible total score was 0, and the maximum was 13. Scores progressively increased with central nerve system maturation.
Time frame: from the start of the intervention to the end of the 3rd day
change of heart rates
monitors recording heart rates
Time frame: from the start of the intervention to the end of the 3rd day
change of respiratory rates
monitors recording respiratory rates
Time frame: from the start of the intervention to the end of the 3rd day
change of pluse oxygen saturation
monitors recording transcutaneous oxygen saturation
Time frame: from the start of the intervention to the end of the 3rd day
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