Impact of Oral Probiotic Blend on Pregnancy Outcome

Inclusion Criteria: * pregnant women aged \> 18 years in the \< 14 week of pregnancy * willing to consume the study product during pregnancy ( V1 to delivery) * willingness to abstain from probiotic food and supplements containing probiotics * written informed consent Exclusion Criteria: Any of the following is regarded as a criterion for exclusion from enrollment in the study: 1. Subjects currently enrolled in another clinical study 2. Subjects having finished another clinical study within the last 4 weeks before inclusion 3. Diabetes mellitus 4. Acute metabolic disorder interfering with glucose metabolism 5. Known cancer \< 5y ago 6. Any ano-rectal infection, disease, surgery in the medical history or current which may have impact on microbiota 7. Anus praeter 8. Hypersensitivity, allergy or idiosyncratic reaction to any component of the test product 9. Any disease or condition which might significantly compromise the hematopoietic, renal, endocrine, pulmonary, hepatic, gastrointestinal, cardiovascular, immunological, central nervous, dermatological or any other body system 10. History of active hepatitis B and C 11. History of HIV infection 12. Regular medical treatment including OTC, which may have impact on the study aims (e.g. probiotics, antibiotic drugs, laxatives etc.) 13. Major cognitive or psychiatric disorders 14. Present drug abuse or alcoholism, reformed alcoholic Legal incapacity