The aim of the present study is to investigate the possibilities of visual field enhancement with electrical stimulation (ES) as a home stimulation method, in a total of 50 patients with optical neuropathy, who have already been treated with ES in the past. Furthermore, factors responsible for response variability and treatment effectiveness are also explored: (i) the role of mental stress (or stress resilience), (ii) the status of biomarkers, such as the systemic stress hormone levels and blood supply to the eye and brain (specifically vascular dysregulation) and (iii) the influence of personality, anxiety, depression and lifestyle. The study serves to further validate this ES procedure for the treatment of visual impairment. Specifically, better efficacy, better compliance, lowest response variability are expected after long-term home use.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
50
Transorbital ACS using 8-12 Hz with 0,5-1,5 mA Intensity, during the first two weeks 1/day, after 2/week for 10 weeks, as a home treatment
Institute of Medical Psychology
Magdeburg, Germany
Visual field size
Static perimetry and high resolution perimetry will be used to measure the visual field sizes
Time frame: 3 months
EEG connectivities in the visual system
EEG recordings will be done using 128 channels, power spectra will be determined
Time frame: 3 months
Level of vascular regulation/dysregulation in the eye
Dynamic vessel analysis will be used the measure blood flow in the eye
Time frame: 3 months
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