Epigenetics Based Diagnosis of Diabetes in Saliva and Blood Samples

Medical University of Vienna224 enrolled

Overview

The aim of the present study is to investigate epigenetics based modifications and biomarkers in the saliva and blood in diabetic patients.

Study Type

OBSERVATIONAL

Enrollment

224

Conditions

Prediabetic State Diabetes Mellitus, Type 2 Ectopic Lipids Epigenetics Based Modifications

Interventions

Blood samplingDIAGNOSTIC_TEST

After a fasting period over night blood samples will be taken.

Saliva and blood samplesDIAGNOSTIC_TEST

After a fasting period over night blood and saliva samples will be taken for the investigation of epigenetics based modifications.

Magnet Resonance SpectroscopyDIAGNOSTIC_TEST

The amount of ectopic lipids in the liver, heart and the skeletal muscle will be measured using 1H-magnetic resonance spectroscopy.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * type 2 diabetic patients * prediabetic patients * women with gestational diabetes * healthy control subjects without diabetes * healthy pregnant women Exclusion Criteria: * cancer disease * infectious diseases such as hepatitis or HIV * malignoms * patients with claustrophoby

Locations (1)

Medical University of Vienna

Vienna, Austria

RECRUITING

Outcomes

Primary Outcomes

Specifying the microRNAs in saliva in diabetic patients

Characterization of microRNAs in saliva of prediabetic and type 2 diabetic patients, as well as in women with gestational diabetes and healthy control subjects.

Time frame: 1 hour

Secondary Outcomes

Correlation of the percentage of liver fat with miRNA´s in diabetic patients.

Correlation of miRNA´s in the saliva with the amount of intrahepatic liver fat.

Time frame: 1 hours

Correlation of the percentage of heart fat with miRNA´s in diabetic patients

Correlation of miRNA´s in the saliva with the amount of ectopic lipids in the heart.

Time frame: 1 hour

Correlation of the percentage of the content of fat in the skeletal muscle with miRNA´s in diabetic patients.

Correlation of miRNA´s in the saliva with the amount of ectopic lipids in the skeletal muscle.

Time frame: 1 hour

Central Contacts

Alexandra Kautzky-Willer, Univ.Prof.Dr.

CONTACT

+434040021260 alexandra.kautzky-willer@meduniwien.ac.at

Michael Leutner, Dr.med.univ., MSc

CONTACT

michael.leutner@meduniwien.ac.at

Data from ClinicalTrials.gov

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