Cyanoacrylate Closure for Treatment of Venous Leg Ulcers

Inclusion Criteria: 1. Age ≥18 years old at time of screening; 2. Venous leg ulcer; 3. Venous insufficiency (\>0.5 seconds; confirmed by Doppler within last 6 months); 4. ABI of ≥0.9; 5. Capable of understanding the study and providing informed consent. Exclusion Criteria: 1. Previous hypersensitivity reactions to the VenaSealTM adhesive or cyanoacrylates; 2. Acute superficial thrombophlebitis; 3. Bilateral treatment 4. Thrombophlebitis migrans; 5. Deep venous thrombosis; 6. Deep venous incompetence or occlusion in external iliac or distal veins in the affected extremity (as assessed based on spontaneity, phasicity, augmentation, pulsatility, and compressibility on ultrasound); 7. Post-thrombotic syndrome; 8. Acute sepsis; 9. Coagulation disorders; 10. Radiation or chemotherapy within 3 months of study; 11. Pregnant or lactating females; 12. Uncontrolled diabetes (HbA1c \>10%); 13. Diabetic foot ulcers; 14. Current use of systemic anticoagulation; 15. Previous treatment of target vein; 16. Tortuous veins; 17. Current participation in another interventional study, or participation within 30 days prior to screening; 18. Inability to tolerate compression, or to receive endovenous treatment.