Hypoglycaemia and Cardiac Arrhythmias in Type 1 Diabetes

Inclusion Criteria: * Informed and written consent * Type 1 diabetes diagnosed according to the criteria of the World Health Organization (WHO) * Age 18-80 years * Fulfilling at least one of the below criteria\*: 1. Recurrent hypoglycaemia (defined as \>1 episode/week with a plasma glucose measurement ≤3.9 mmol/l within the last 4 weeks) 2. An episode of severe hypoglycaemia within the last year (according to the ADA definition, an event requiring assistance of another person to actively administer carbohydrates and/or glucagon, or take other corrective actions) 3. Hypoglycaemic symptom unawareness (history of impaired autonomic response during hypoglycaemia) (\*The aim is that all patients will fulfil criteria a or b. If the targeted sample size cannot be recruited, patients fulfilling criteria c will be included) * Insulin treatment * One or more clinical relevant complications to diabetes defined as\*\*: 1. Nephropathy (creatinine \>130 μmol/l and/or microalbuminuria) 2. Macrovascular disease defined as coronary disease (stable angina pectoris. previous unstable angina pectoris or myocardial infarction), cerebrovascular disease (previous stroke or transitional cerebral ischaemia), and peripheral vascular disease (previous intermittent claudication or prior acute ischemia) 3. Peripheral neuropathy with vibration perception threshold of \>25 volt determined by biothesiometry 4. Moderate to severe retinopathy * Well-functioning ILR during run-in period (acceptable readings judged by an arrhythmologist) * Participation in the extended study (\*\*The aim is that all patients will fulfil criteria a or b. If the targeted sample size cannot be recruited, patients fulfilling criteria c or d will be included) Exclusion Criteria: * Arrhythmia diagnosed prior to the screening visit * ICD or pacemaker at the time of inclusion * Severe heart failure (left ventricular ejection fraction \<25%) * Structural heart disease (Wolf-Parkinson-White syndrome, congenital heart disease, severe valve disease) * Thyroid dysfunction (except for well-regulated eltroxine substituted myxoedema)