This is a systemic research of Chinese aortic coarctation patients, aiming to determine risk factors and serial biomarkers of aortic coarctation in prognosis.
The goal is to determine how much the left ventricle remodeling pre-operation and how it changes in the following-up duration after surgery, so does in the blood pressure and heart function. Risk factors associated with complications and prognosis are investigated and analyzed. Identification of novel biomarkers is needed to help predicting the prognosis, such as the left ventricle anti-remodeling, heart function and blood pressure improvement, as well as the exercise tolerance post-operation. The findings of this study will help the investigators developping new tests to monitor affected patients and optimize the operation as well as the follow-up procedure.
Study Type
OBSERVATIONAL
Enrollment
300
Beijing Anzhen Hospital
Beijing, Beijing Municipality, China
RECRUITINGChange in left ventricular mass
Left ventricular mass will be measured by 2D echocardiography. For the retrospective cohort, the data is collected from the cases' medical record, and during follow-up visit.
Time frame: Prior to primary treatment and during follow-up visit(one month to 20 years for retrospective cohort and one year for prospective cohort)
Hypertension
Both resting blood pressure and exercise-related blood pressure will be assessed for patients above 5 years old during the follow-up visit.
Time frame: one month to 20 years after primary treatment for retrospective cohort and one year after primary treatment for prospective cohort
Left ventricular systolic function
Left ventricular systolic function assessed by echocardiography
Time frame: one month to 20 years after primary treatment for retrospective cohort and one year after primary treatment for prospective cohort
Left ventricular diastolic function
Left ventricular diastolic function assessed by echocardiography (TDI)
Time frame: one month to 20 years after primary treatment for retrospective cohort and one year after primary treatment for prospective cohort
Left ventricular systolic heart function of longitudinal myocardium
Left ventricular systolic heart function of longitudinal myocardium assessed by echocardiography (M mode Doppler).
Time frame: one month to 20 years after primary treatment for retrospective cohort and one year after primary treatment for prospective cohort
Exercise tolerance
Six minutes walking distance will be recorded and analyzed to evaluate the exercise tolerance. Echocardiographic images will be obtained after six minutes walking to assess the reserve function of left ventricle. Blood pressure will also be taken immediately after the Six minutes walking to analyze exercise-induced hypertension.
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Time frame: one month to 20 years after primary treatment for retrospective cohort and one year after primary treatment for prospective cohort
Biomarkers of vascular inflammation
Biomarkers of inflammation (hs-CRP). For the retrospective cohort, the data is collected from the cases' medical record, and during follow-up visit.
Time frame: Prior to primary treatment and during follow-up visit(one month to 20 years for retrospective cohort and one year for prospective cohort)
Biomarkers of left ventricle remodeling
Biomarkers of left ventricle remodeling (ST2)
Time frame: For the retrospective cohort, follow-up visit of 1 month to 20 years after primary treatment. For the prospective cohort, the data is collected prior to primary treatment and during follow-up visit of one year after primary treatment
Biomarkers of left heart function
Biomarkers of left heart function (BNP). For the retrospective cohort, the data is collected from the cases' medical record, and during follow-up visit.
Time frame: Prior to primary treatment and during follow-up visit(one month to 20 years for retrospective cohort and one year for prospective cohort)
Biomarkers of hypertension phenotype related to aortic coarctation
Biomarkers of hypertension phenotype related to aortic coarctation
Time frame: one month to 20 years after primary treatment for retrospective cohort and one year after primary treatment for prospective cohort
Recoarctation
Recoarctation assessed by echocardiography or computed tomography angiography.
Time frame: one month to 20 years after primary treatment for retrospective cohort and one year after primary treatment for prospective cohort
All-cause death
The data is collected during follow-up visit at follow-up time point.
Time frame: 20 years after primary treatment for retrospective cohort and one year after primary treatment for prospective cohort