The investigators performed a randomized controlled trial with investigator-masked design enrolling subjects with acute myocardial infarction. The purpose of this study is to find a treatment strategy to reduce the risk of recurrence of myocardial infarction through oral hygiene improvement.
Subjects were divided into a treatment group and a control group. Both sides receive basic periodontal examinations, but the treatment group receives active dental procedure such as scaling and root planing. Both groups also receive post-myocardial infarction management. As part of a pilot study, this study used the primary outcome measure for changes in surrogate markers rather than clinical outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
68
scaling and root planing
aspirin, clopidogrel, ticagrelor
panorama radiograph : full mouth periapical radiograph
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
RECRUITINGhsCRP
hsCRP(high sensitivity C-reactive protein), mg/dL
Time frame: at 3 months
surrogate blood markers
FBS \& Total cholesterol \& LDL-cholesterol \& HDL-cholesterol \& Triglyceride \& Apolipoprotein A \& Apolipoprotein B, mg/dL
Time frame: at 3 months
patient symptom
NYHA functional class
Time frame: at 3 months & 12 months
Systolic & diastolic blood pressure
automated blood pressure, mmHg
Time frame: at 3 months & 12 months
Exercise performance
Treadmill test
Time frame: at 3 months
Death
number of cardiovascular death
Time frame: at 12 months
unscheduled coronary revascularization
number of unscheduled coronary revascularization
Time frame: at 12 months
stroke
number of stroke
Time frame: at 12 months
HF admission
number of HF admission
Time frame: at 12 months
unstable angina
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number of unstable angina
Time frame: at 12 months
recurrent MI
number of recent MI
Time frame: at 12 months