Toripalimab in Combination With Platinum Plus Etoposidein Patients With Extensive-Stage Small Cell Lung Cancer

Inclusion Criteria: 1. ≥18 years , male or female; 2. Histologically or cytologically confirmed ES-SCLC (per the Veterans Administration Lung Study Group (VALG) staging system 3. ECOG PS 0\~1; 4. No prior treatment or immunocheckpoint inhibitors for ES-SCLC; 5. Treatment-free for at least 6 months since last chemo/radiotherapy, among those treated (with curative intent) with prior chemo/radiotherapy for limited-stage SCLC； 6. Patients with asymptomatic brain metastases who have received previous treatment 7. Has provided tumor tissue samples 8. Estimated survival time ≥8 weeks; 9. There is at least one measurable lesion that conforms to RECIST criteria v1.1.For lesions that have received previous radiation therapy, the lesion can only be included in the measurable lesion if the disease progression is clear after radiotherapy and the lesion is not the only measurable lesion. 10. Before the first dose of the study drug, it should have appropriate organ function, and the laboratory test value should meet the protocol. 11. Has adequate hematologic and end organ function Exclusion Criteria: 1. Prior systemtic treatment for ES-SCLC; 2. Prior treatment with any CD137 agnist or immunocheckpoint inhibitors. 3. Subjects with active or untreated central nervous system (CNS) tumor metastasis; 4. Spinal cord compression not definitively treated with surgery and/or radiation or previously diagnosed and treated spinal cord compression without evidence that disease has been clinically stable for ≥ 1 week prior to randomization 5. Cancerous meningitis; 6. Uncontrolled or symptomatic hypercalcemia; 7. Other malignant tumors within 5 years prior to the first dose of study treatment 8. Subjects with any active, known or suspected autoimmune disease; 9. History of idiopathic pulmonary fibrosis, drug-induced pneumonitis,or evidence of active pneumonitis . 10. Subjects who received major surgery within 28 days prior to enrollment or were not fully recovered from prior surgery; 11. Significant cardiovascular disease, such as New York Heart Assoc