Kisspeptin/GPR54 Pathway and Early Puberty

Shenzhen Center for Disease Control and Prevention628 enrolled

Overview

There was a worldwide early trend in girls'age for puberty onset. The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study was designed to explored the association of polymorphisms in KISS1/GPR54 pathway genes and the risk of early puberty in Chinese Han girls.

Study Type

OBSERVATIONAL

Enrollment

628

Conditions

Puberty, Precocious

Interventions

this study was an observational study and no interventions were given to the participantsOTHER

the participants were recruited and the data as well as blood sample were collected.

Eligibility

Sex: FEMALEMin age: 7 YearsMax age: 10 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: \- Clinical diagnosis of central precocious puberty or early and fast puberty. Exclusion Criteria: * The participants who were not the first visit to the hospital and had been treated before. * The participants who were with endocrine disorders.

Outcomes

Primary Outcomes

the polymorphism in the KISS1/GPR54 pathway genes

functional SNP loci of the KISS1/GPR54 pathway genes KISS1, KISSIR, PLCB1, PRKCA, and ITPR1 were selected and detected.

Time frame: 3 months

Data from ClinicalTrials.gov

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