A Registered Cohort Study on Wilson's Disease

Wan-Jin Chen2,000 enrolled

Overview

The aim of this study is to determine the clinical spectrum and natural progression of Wilson's Disease in a prospective multicenter natural history study, to assess the clinical, genetic, epigenetic features and biomarkers of patients with Wilson's Disease to optimize clinical management.

Study Type

OBSERVATIONAL

Enrollment

2,000

Conditions

Wilson's Disease

Interventions

No interventionOTHER

No intervention

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with the genetic diagnosis of Wilson's Disease * Asymptomatic Wilson's Disease carriers * Relatives of Wilson's Disease patients or carriers * Unrelated healthy controls * Participants or Parent(s)/legal guardian(s) willing and able to complete the informed consent process Exclusion Criteria: \* Participants are unable to comply with study procedures and visit schedule

Locations (1)

First Affiliated Hospital of Fujian Medical University

Fuzhou, China

RECRUITING

Outcomes

Primary Outcomes

The change of Unified Wilson's Disease Rating Scale (UWDRS)

Disease severity will be assessed by application of the Unified Wilson's Disease Rating Scale (UWDRS), a clinical rating scale consists of three subscales. Higher UWDRS total scores indicate more severe disease.

Time frame: Up to 30years

Central Contacts

Jin He, MD

CONTACT

86-0591-87982772 hejinfjmu@hotmail.com

Yi Lin, MD.PhD

CONTACT

8613615039153 linyi7811@163.com

Data from ClinicalTrials.gov

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