Effect of Magnesium on Dose of Rocuronium for Deep Neuromuscular Blockade

Seoul National University Bundang Hospital68 enrolled

Overview

It is well known that magnesium enhances the effect of neuromuscular blocking agents such as rocuronium. However, it is not known how much magnesium can reduce neuromuscular blocking agents in maintaining deep neuromuscular blockade. Through this study, the investigators will quantitatively analyze the rocuronium saving effect of magnesium.

It is well known that magnesium potentiate the effect of neuromuscular blocking agents. It prolonged the duration of rocuronium and reduces the onset time of rocuronium. Magnesium acts on motor end plate, where magnesium reduces the release of prejunctional acetylcholine, thereby decreasing the muscle membrane excitability. However, the quantitative rocuronium saving effect of magnesium is not clear. This study's hypothesis is that magnesium would reduce the amount of rocuronium. And the investigators want to evaluate how much magnesium can reduce the amount of rocuronium. Secondary outcome is the effects of magnesium on recovery time, postoperative pain, nausea and vomiting.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Magnesium Sulfate Causing Adverse Effects in Therapeutic Use Neuromuscular Blockade

Interventions

Magnesium SulfateDRUG

magnesium sulphate 50mg/kg in normal saline 50ml infusion for 10minutes for loading dose followed by 15mg/kg/hr for continuous infusion

PlaceboDRUG

Normal Saline 50ml infusion for loading dose followed by continuous infusion for same dose of magnesium.

Eligibility

Sex: MALEMin age: 20 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who undergo elective robot assisted radical prostatectomy, between 20 and 80 years with a American Society of Anesthesiologists physical status classification of I or II Exclusion Criteria: * Conduction abnormalities in preoperative EKG such as Atrioventricular block, sinus pause * Glomerular filtration rate \<60ml/min/1.73m2 * Allergy to rocuronium, sugammadex, magnesium * Medications that interfered with muscle activity * Neuromuscular disease * Hypermagnesemia

Locations (1)

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Outcomes

Primary Outcomes

rocuronium amount

total rocuronium/weight/infusion time

Time frame: perioperative - until 48hours

Secondary Outcomes

recovery time

time from sugammadex injection to Train-of-four ratio 0.9

Time frame: perioperative - until 48hours

postoperative pain

11 point Numerical Rating Scale; 0 (no pain) to 10 (worst imaginable pain), rescue medication

Time frame: at postoperative 30minutes, 6hours, 24hours

postoperative nausea and vomiting

Numerical Rating Scale(0-10), rescue medication

Time frame: at postoperative 30minutes, 6hours, 24hours

Data from ClinicalTrials.gov

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