The investigators are doing this study to determine if there are body composition changes after a 12-week exercise program in breast cancer patients and determine what factors contribute to sustained physical activity after the 12-week exercise program intervention.
The study is enrolling breast cancer patients up to 2 years after their diagnosis in a 12-week exercise program. The participants will either participate in: Group 1-participating in an exercise program with biometric evaluations or Group 2-biometric evaluations but not participating in the exercise program. At the end of the 12-week exercise program, participants in Group 1 will be randomized to either: a) continuing with exercise group classes or b) continuing with exercise individual classes. Both Group 1a and 1b participants will be followed for the remainder of the year and be evaluated for continued physical activity. All Group study participants' biometrics will be assessed at baseline and at the end of 12-weeks, with continued annual medical review follow-up for a total of 5 years.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
62
First Intervention 12-week exercise program, 3 days/week, 90min exercise sessions at the Rehabilitation Hospital of the Pacific. Private or semi-private (1:1 or 2:1 ratio participant to instructor) sessions, led by Kinesiology students Second Intervention- 12-week exercise program, 2 days/week, 90min exercise sessions at the Rehabilitation Hospital of the Pacific. Group Fitness Classes
University of Hawaii Cancer Center
Honolulu, Hawaii, United States
Fat mass
Measure fat mass (arms, legs, trunk and total) in kg using Dual energy X-ray absorptiometry (DXA) data
Time frame: 1 day
Isometric peak torque
Measure the peak torque value generated during isometric knee extension/flexion movement evaluation at 60 degrees will be assessed with the HUMAC NORM device
Time frame: 1 day
Lean mass
Measure lean mass (arms, legs, trunk and total) in kg using Dual energy X-ray absorptiometry (DXA) data
Time frame: 1 day
Bone mass
Measure bone mass (arms, legs, trunk and total) in kg using Dual energy X-ray absorptiometry (DXA) data
Time frame: 1 day
Waist to Hip ratio (WHR) from manual tape measurement
Manual physical anthropometry of waist and hip circumferences
Time frame: 1 day
Automatic 3D optical (3DO) scan measurement: girth measurement
Automated 3DO measurements generate the following: girth in cm measurements across the whole body
Time frame: 1 day
Muscle Function
Measure the peak torque value generated during isometric knee extension/flexion movement evaluation at 60 degrees will be assessed with the HUMAC NORM device
Time frame: 1 day
Percent fat
Percent fat (arms, legs, trunk and total) using Dual energy X-ray absorptiometry (DXA) data
Time frame: 1 day
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Automatic 3D optical (3DO) scan measurement: length measurement
Automated 3DO measurements generate the following: length in cm measurements across the whole body
Time frame: 1 day
Automatic 3D optical (3DO) scan measurement: volume measurement
Automated 3DO measurements generate the following: volume in cm measurements across the whole body
Time frame: 1 day
Bone Mineral Density (spine and total) using Dual energy X-ray absorptiometry (DXA) data
Bone Mineral Density (spine and total) using Dual energy X-ray absorptiometry (DXA) data
Time frame: 1 day
Recurrence Free Survival
obtained from last physician note
Time frame: 5 years
BIBCQ-Body Image After Breast Cancer questionnaire
45 items
Time frame: 5 years
BFI-Brief Fatigue Innovatory questionnaire
9 items
Time frame: 5 years
PHQ-9- Patient Health (Depression) questionnaire
9 items
Time frame: 5 years
FACT-G-Functional Assessment of Cancer Therapy-General (Comorbidities)questionnaire
27 items
Time frame: 5 years
Diet History Questionnaire II
Self-reported energy intake, measured as kcal/day
Time frame: 5 years
Biomarkers
Adipokines: leptin, HMW-high molecular weight adiponectin, PAI1-plasminogen activator inhibitor Cytokines \& Inflammation: TNF-tumor necrosis factor α, IL-interleukin 1β, IL2, IL4, IL5, IL6, IL8, IL10, interferon, CRP-C reactive protein, uric acid, cortisol Insulin Resistance \& IGFs: glucose, insulin, Hb-hemoglobin A1C, IGF-insulin growth factor 1, IGFBP-insulin like growth factor binding protein 1-3 Sex Steroid Hormones: total estradiol \& estrone, total testosterone, SHBG-sex hormone-binding globulin (for free estradiol and free testosterone will be derived) Lipid Profile \& Lipid-soluble Micronutrients: TG-triglycerides , total cholesterol, HDLC-high density lipoprotein cholesterol , free fatty acids, lycopene, 25OH-vitamin D3, alpha-tocopherol Liver Enzymes: ALT-alanine aminotransferase Neuropeptides \& Gut Hormones: ghrelin MOTS-mitochondrial derived peptide-c
Time frame: 5 years