Mechanical bowel preparation for left-sided colorectal surgery remains standard in most cases. However, there are some discrepancies on how to prepare the bowl, while rectal enema and oral agents are both available methods. The knowledge of intestinal microbiome role on surgical outcomes is increasing, since few recent reports linked microbiome composition to postoperative complications, such as anastomotic insufficiency. Although, it is not clear how the bowel preparation affects the gut microbiome. Therefore, different bowel preparation techniques impact on gut microbiome will be studied.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
40
1. Oral-agents for mechanical bowel preparation prior to left-side colorectal resection 2. Enema for mechanical bowel preparation prior to left-side colorectal resection
National Cancer Institute
Vilnius, Lithuania
Intestinal microbiome composition
Significant differences in the beta-diversity of the intestinal microbiome between oral and enema groups
Time frame: 6 days after surgery
Intestinal microbiome composition
Significant differences in the beta-diversity of the intestinal microbiome between oral and enema groups
Time frame: 30 days after surgery
Intestinal microbiome composition
Significant differences in the alpha-diversity of the intestinal microbiome between oral and enema groups
Time frame: 6 and 30 days after surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.