Efficacy and Safety of Skin Care Product in Aging Facial Skin

Inclusion Criteria: 1. Females 40\~65 years of age; 2. Subjects are not found with facial skin tissue changes or inflammation as determined by the investigator ; 3. Has skin aging of Glogau class II, i.e. presence of wrinkles during facial movement or resting, as determined by the investigator; 4. The subject is able to understand and comply with the requirements, instructions and restrictions specified in the protocol; and 5. Sign on the informed consent form. Exclusion Criteria: 1. Received active facial treatment including laser, pulse light, CPT Thermage, HIFU lifting or subcutaneous filler injection in the last 6 months; 2. Has history of chronic skin condition or autoimmune disorders such as atopic dermatitis, psoriasis, chronic urticaria, vitiligo, rosacea or keloid; 3. Has history of allergy to the study skin care product (P29429-01) compositions, moisturizer or sunscreen; 4. Pregnant or breastfeeding women; 5. Received hormone medications such as estrogen or progesterone, or health foods such as royal jelly, soybean isoflavone, red clover, black cohosh, Chinese Angelica, evening primrose oil, borage oil, chasteberry or placenta extract within 30 days before the study; 6. Required treatment for any acute condition or infection within 14 days before the study; 7. Experienced a serious medical condition such as disease of the heart, lungs, brain and/or liver within 3 months before the study; 8. Has been a routine smoker within 12 months before the study; 9. Currently has malignant tumor; 10. Has used any medicine for skin use on the face that is deemed to interfere with the study within 30 days before the study by investigator; 11. Has participated in another clinical trial within 30 days before the study; 12. Receiving medical management that may affect the ability to participate in this study; 13. Inappropriate for participating in this study as deemed by the principal investigator. Inclusion Criteria for Substudy: 1. Has provided written informed consent for the main study; 2. Subjects are not found with tissue changes or inflammation at the planned biopsy site on medial forearm skin as determined by the principal investigator or dermatologist; 3. The subject is able to understand and comply with the requirements, instructions and restrictions specified in the substudy; 4. Sign and date on the informed consent form of the substudy. Exclusion Criteria for Substudy: 1. Currently using anticoagulants; 2. Patients with severe coagulation disorder; 3. Patients with keloid predisposition.