Idiopathic Pulmonary Fibrosis and Serum Bank

Rennes University Hospital903 enrolled

Overview

Idiopathic pulmonary fibrosis (IPF) is the most common form of chronic idiopathic diffuse interstitial lung disease (DILD) in adults. It is a fibroproliferative, irreversible disease of unknown cause, usually progressive, occurring mainly from the age of 60 and limited to the lungs. IPF is a serious disease with a median survival rate at diagnosis of 3 years. The aim of the study is to set up a biocollection of serum from patients in a context of idiopathic DILD and a possible or confirmed diagnosis of common interstitial lung disease by chest CT. Patients will be recruited at the consultations of the Rennes Rare Lung Disease Competence Centre. These will be patients in stable condition or in acute exacerbation of IPF.

This study will initially focus on circulating serum CD163 markers, but a broader proteomics approach could be considered in a second phase to look for other markers of lung diseases.

Study Type

OBSERVATIONAL

Enrollment

903

Conditions

Idiopathic Pulmonary Fibrosis Lung Diseases, Interstitial

Interventions

Three additional blood tubes (3 x 8mL) will be collected for this study. They will be added to the traditional diagnostic assessment carried out for their IPF, during their consultation at the competence centre for rare lung diseases. These samples will be taken by a registered nurse in the presence and under the responsibility of the investigator.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients seen on an outpatient basis and in stable or acute condition * Patient over 18 years of age. * The inclusion criteria will be those edited by the American Thoracic Society (ATS) and the European Respiratory Society (ERS) to diagnosis IPF Exclusion Criteria: * Patients who are unable or unwilling to sign the consent.

Outcomes

Primary Outcomes

Determination of circulating CD163 serum concentration

Serum CD163 levels in patients with possible or certain DILD will be performed by ELISA technique (R\&D Systems kit, Minneapolis, MN).

Time frame: Through study completion, an average of 4 years