Remote Ischemic Preconditioning During Lower Limb Revascularization

University of Messina50 enrolled

Overview

The aim of this study is to evaluate the role of remote ischemic preconditioning (RIPC) in preventing acute kidney injury after lower limb revascularization. Remote ischemic preconditioning(RIPC) is a simple, cost-free and non invasive procedure (transient upper limb ischemia/reperfusion) that could provide organ protection (Heart, Brain and Kidney) following ischemia injuries.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Ischemic Preconditioning Acute Kidney Injury Limb Ischemia

Interventions

RIPCPROCEDURE

4 cycles of 5-min inflation to 200 mmHg followed by 5-min deflation of arm cuff

ControlPROCEDURE

deflated cuff placed on the left arm for 40 min

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients scheduled for open limb revascularization Exclusion Criteria: * Peripheral vascular disease affecting upper limbs * Chronic kidney disease in stage 4 or 5 (eGFR\<30 ml/min/1,73m2) * Patients underwent contrast-enhanced radiological exams in the previous 7 days * Treatment with glibencamide or prostaglandins

Locations (1)

A.O.U. G.Martino - University of Messina

Messina, Italy

Outcomes

Primary Outcomes

AKI

the incidence of Acute Kidney Injury, defined as absolute rise of ≥ 0.3 mg/dL and/or a relative increase of 25% in serum creatinine compared to preoperative

Time frame: 72 Hours

AKI

the incidence of Acute Kidney Injury, defined as decrease of 35% in GFR compared to preoperative.

Time frame: 72 Hours

Secondary Outcomes

AKI Risk Score

the incidence of Acute Kidney Injury, defined as increase od 0.3 in Aki risk score (TIMP-2 \* IGFBP-7)

Time frame: 24 Hours

Data from ClinicalTrials.gov

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