Probiotics Attenuate Postoperative Cognition Decline

RenJi Hospital220 enrolled

Overview

The aim of this study was to evaluate whether perioperative probiotics can reduce the incidence of postoperative cognitive dysfunction and postoperative delirium.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

220

Conditions

Necrosis of Femoral Head Knee Osteoarthritis Fracture of Neck of Femur Lumbar Disc Herniation

Interventions

Bifidobacterium triple live capsuleDRUG

Bifidobacterium triple live capsules, indications for acute and chronic diarrhea and constipation caused by intestinal flora imbalance, can also be used for the treatment of mild to moderate acute diarrhea, chronic diarrhea and indigestion, bloating, and adjuvant treatment of intestinal flora Endotoxemia caused by disorders.

PlacebosDRUG

Placebos were administrated as same as the bifidobacterium live capsule

Eligibility

Sex: ALLMin age: 65 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. . Age is greater than or equal to 65 years old 2. . Can communicate normally 3. . Selective knee ankle, hip replacement or lumbar open reduction and internal fixation under general anesthesia 4. . ASA graded at I-II level 5. . Patient or family informed consent Exclusion Criteria: 1. . Have a brain disease, or have a history of brain disease 2. .MMSE check of less than 24 points. 3. . History of neurological and psychological disorders including AD, stroke, psychosis 4. . Serious hearing or visual impairment 5. . Preoperative systolic blood pressure \>190mmhg, or diastolic blood pressure \>100mmhg 6. . The patient or family refuses

Locations (3)

Renji Hospital

Shanghai, Shanghai Municipality, China

RECRUITING

Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine

Shanghai, Shanghai Municipality, China

RECRUITING

Jin Cheng people's hospital

Jincheng, Shanxi, China

RECRUITING

Outcomes

Primary Outcomes

Incidence of POCD 7days after surgery

Time frame: The seventh day after surgery

Secondary Outcomes

Incidence of POCD 1 month after operation

Time frame: One month after surgery

Incidence of POD 7 days after surgery

Use the CAM scale to assess whether a patient has postoperative delirium

Time frame: One day after surgery to the seventh day after surgery

Central Contacts

tang ying, Bachelor

CONTACT

13918859887 421941497@qq.com

su diansan, Doctor

CONTACT

18616514088 184872238@qq.com

Data from ClinicalTrials.gov

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