To determine whether a lacto-ovo vegetarian diet is effective in improving gastrointestinal symptoms, quality-of-life, intestinal inflammation and gut microbiota composition in mild-to-moderate IBD compared to a standard omnivorous diet.
This study will review whether a lacto-ovo vegetarian diet is an optimal dietary therapy to achieve a clinical response in mild to moderate UC and CD as an adjunctive treatment to current medical therapies. The proposed studyT will be used to evaluate the efficacy of a lacto-ovo vegetarian diet together with its effect on the microbiota to create an enhanced understanding of the role diet plays in the management midl to moderate IBD. Using a socially acceptable diet it is anticipated that food-related quality-of-life measures will improve for participants. Dietary modification could be a more economical, safer and more effective means of reducing symptoms and flare-ups compared to pharmacological therapy.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
21
Lacto-ovo vegetarian diet inclusive of dairy and eggs
Liverpool Hospital
Sydney, New South Wales, Australia
St John of God Subiaco Hospital
Perth, Western Australia, Australia
Fiona Stanley Fremantle Hospitals Group
Perth, Western Australia, Australia
Royal Perth Hospital
Perth, Western Australia, Australia
Number of participants with a clinical response at week 8
A clinical response is defined as a decrease from baseline in the total Mayo score of at least three points, with an accompanying decrease in the subscore for rectal bleeding or at least 1 point or an absolute subscore for rectal bleeding of 0 or 1
Time frame: Week 8
Number of participants achieving clinical remission at week 8
A clinical remission is defined by a total Mayo score of 2 points or lower, with no individual subscore exceeding 1 point or a reduction in HBI of three points
Time frame: Week 8
Number of participants with changes to IBDQ score at week 8
Change in total score from baselines. IBDQ - normal quality of life score is 170 points (range 32 to 224) and a quality of life response is a change of 16 points.
Time frame: Week 8
Participants Food related quality of life in IBD (Fr-QoL 29) score at week 8
Change in total score from baseline. Lowest score of 29 reflects poor quality of life, maximum score of 145 reflects highest quality of life score.
Time frame: Week 8
Participants SF-36 quality of life score at week 8
SF-36- change in total score from baseline. A score of 0 reflects maximum disability, the maximum score of 100 reflects no disability.
Time frame: Week 8
Number of participants achieving a change in gut microbiome diversity at week 8
The gut microbiome will be examined using ITS2, 16S rRNA gene and metagenomics.
Time frame: Week 8
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Number of participants with a change in beneficial gut metabolome profile at week 8
Untargeted metabolomics will be performed on stool samples using high-resolution Gas Chromatography Mass Spectrometry (GC-Orbitrap-MS). Metabolite identification will be established prior to statistical analysis, by matching against an in-house MS/MS spectral library of 900 metabolites and searching online spectral libraries (mzCloud, Metlin, HMDB and Massbank).
Time frame: Week 8