Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption. It is usually recommended to take metformin during the meal to decrease gastrointestinal side effects. However, if metformin decreases carbohydrate absorption, this might not be the most efficient intake. To study the influence of preprandial metformin administration on carbohydrate absorption, it will repeat 3 oral glucose tolerance test on obese dysglycemic patients, without metformin or with metformin administer 30 or 60 minutes before. We will also evaluate how it impacts gastrointestinal tolerance.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
24
Each participant will have 3 OGTT, one without metformin, one with metformin30 minutes before the test, one with metformin 60 minutes before the test. The order for each test will be randomized.
Area under the curve of D-Xylose
Time frame: During the 3 hours OGTT
Number of Participants with gastrointestinal side effects
Time frame: During the 3 hours OGTT
Area under the curve of blood glucose
Time frame: During the 3 hours OGTT
Area under the curve of insulin
Time frame: During the 3 hours OGTT
Area under the curve of GLP-1
Time frame: During the 3 hours OGTT
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