With the increasing popularity of endothelial keratoplasty, a coincident increase in the rate of fungal infections post-keratoplasty has been seen in the United States. In this study, the eye bank will harvest pairs of donor corneas and randomize one cornea from each pair to be stored in Optisol-GS per Eye Bank Association of America guidelines. The eye bank will add amphotericin B 0.255 μg/mL (antifungal) to the storage solution for the mate cornea. The study donor corneas will be assigned to participants who are scheduled to undergo Descemet membrane endothelial keratoplasty. The surgeons, participants, and evaluators will remain masked regarding the donor cornea storage solution assignment. The participants will be followed for 6 months.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Drug concentration: 0.255 μg/mL
Price Vision Group
Indianapolis, Indiana, United States
Endothelial cell density
Central corneal endothelial cell density will be assessed by specular microscopy
Time frame: 6 months
Incidence of post-keratoplasty fungal keratitis
The incidence of post-keratoplasty fungal keratitis will be assessed.
Time frame: 6 months
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