Regenerative Endodontic Treatment of Mature Necrotic Teeth With Apical Periodontitis

Cairo University36 enrolled

Overview

The aim of this prospective, randomized, controlled double-blind study is to evaluate the effectiveness of biodentine compared with MTA used as pulp space barrier on discoloration of teeth after regenerative based non-obturation root canal treatment in mature single canal with pulp necrosis and apical periodontitis.

• Regenerative endodontic treatment will be performed through two visits: First visit aims to clean and disinfect the tooth canal by copious irrigation with NaOCL and EDTA solution . At the end of first visit, canal will be dressed by CaOH as intracanal medicaments. Second visit will be after two weeks. After removal of CaOH dressing by copius irrigation, evoking bleeding inside canal by over instrumentation. When blood become semi-coagulated, according to the random sequence number of the participants, either biodentine or white MTA will be placed as pulp space barrier. At the end of treatment, the access cavity will be sealed with composite restoration.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Necrotic Pulp Apical Periodontitis

Interventions

BiodentineOTHER

Biodentine is calcium silicate based cement which is bioactive and inductive material. Biodentine will be applied as coronal plug material.

White MTAOTHER

MTA is calcium silicate based cement which is bioactive and inductive material. MTA is used in most cases of regenerative endodontics and it will be applied as coronal plug material.

Eligibility

Sex: ALLMin age: 10 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Tooth type: single-rooted teeth (anterior or premolar) encasing of one root canal with mature root (closed apex). 2. Negative response of pulp tissue to electrical or thermal pulp tester. 3. Widening in lamina dura or periapical radiolucency not more than 3 mm. Exclusion Criteria: * 1\. Patients having significant systemic disorder or immunocompromised patients. 2. Teeth with generalized chronic periodontitis or have periodontal pocket larger than 3 mm. 3\. Teeth with developmental anomalies (i.e, dens invaginatusor a palatogingival groove). 4\. Teeth with previous root canal. 5. Teeth need to post and core as final restoration

Locations (1)

Dentistry Faculty

Cairo, Egypt

Outcomes

Primary Outcomes

Discoloration of teeth

Discoloration of teeth that will be assessed clinically through follow up period 3, 6, 9, 12 months by visual examination and by using color shade guide (Tetric N shade guide, Ivoclar Vivadent) whether tooth discolored or not in comparison with the original preoperative color shade.

Time frame: Up to one Year after completion of regenerative endodontic treatment

Secondary Outcomes

Healing of Periapical Tissue

Healing of periapical tissue will be assessed clinically and radiographically through follow up period: 3, 6, 9, 12 months. When the case is clinically asymptomatic: (without sinus tract, swelling, with no palpation, or percussions pain) and radiographically showed absence or reduction of the radiolucency are together will considered successful of regenerative treatment.

Time frame: after 3, 6,9 and Up to 12 months after completion of regenerative endodontic treatment

Restoring the sensibility of tooth

Electric pulp tester (EPT)

Time frame: after 6,9 and Up to 12 months after completion of regenerative endodontic treatment

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.